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The 2008 Mercedes E350 features a wheel bolt pattern of 5 bolts with a distance of 112mm between each bolt. When purchasing new wheels, be sure to choose ones with this specific bolt pattern. Although adapter plates are available, they can potentially damage your wheel hubs or the wheels. It's advisable to consult with a reliable tire and wheel shop for a range of suitable wheel options for your car. It's generally recommended not to exceed a size increase of more than 2 inches from stock to avoid issues like rubbing during turns or over bumps.
The 2008 Mercedes E350 has a wheel bolt pattern of 5x112mm.