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The 2016 Mercedes-Benz E350 comes with 0W-40 synthetic oil straight from the factory and has a 6.9-quart capacity including the filter. This vehicle can handle different oil viscosities well due to its advanced engineering. While 0W-30 and 0W-40 are recommended for all temperatures, you can use up to 20W-50 if you live in a place where it never gets colder than 20 degrees Fahrenheit. Thinner oils provide better lubrication for your engine parts. Mobil 1's European Car Formula Synthetic Motor Oil, priced around $10 per quart, works perfectly in the E350. When draining the oil, be cautious not to tighten the drain plug with more than 22 pound-feet of torque to avoid stripping it and needing a replacement, an all-too-common mistake.
The 2016 Mercedes E350 requires SAE 5W-40 oil for its engine.