Vehicle Questions and Answers
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The fuel filter in a 2000 Ford F-250 is situated in the fuel filter housing near the front of the engine under the hood on the driver's side. There is also a second filter underneath the truck, but you usually only need to change the one in the engine. A good choice for replacing it in your truck is the FD-4596, which costs about $14 on Amazon and works just as well as the original part.
The fuel filter on a 2000 Ford F250 is typically located along the frame rail, near the center of the truck's body.