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The 2010 Cadillac Escalade equipped with the 6L80 automatic transmission requires a total of 12.4 quarts (initially 6.0 quarts) of DEXRON-Vi Automatic transmission fluid. It's crucial to change your transmission fluid every 25,000 to 40,000 miles to prevent damage, and also check the levels every 5,000 to 10,000 miles. Running low on fluid can cause significant harm. As you probably know, replacing a transmission can be costly, so it's wise to maintain proper levels to avoid overheating and potential failure.
The best transmission fluid to use for the 2010 Cadillac Escalade is the full synthetic Dexron VI automatic transmission fluid.