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The 2011 Mercedes E350 may encounter transmission issues such as fluid leaks or noisy operation. It is recommended to change the transmission fluid every 30,000 to 60,000 miles to prevent these problems. Neglecting fluid maintenance could result in unpleasant sounds from the transmission and difficulty with the torque converter. As the transmission is a vital component of the vehicle, problems are likely to arise eventually, such as stuck gears, jerking, hard shifts, and shudders. Delayed shifts may lead to acceleration issues, and a slipping transmission should be addressed promptly if fluid leaks occur.
Issues with slipping and shifting are being experienced with the 2011 Mercedes E350's transmission.