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The 2000 Ford F-250 equipped with a 6.8 L V10 engine requires 6 quarts of semi-synthetic SAE 5W-20 engine oil, including the filter. It is recommended to use a Motorcraft FL-820 filter, which can be purchased for under $15. Opting for a high mileage oil might be beneficial for a vehicle of this age, as it can help clean up accumulated oil sludge in engines with over 75,000 miles.
For the 2000 Ford F-250 V10, it is advised to opt for 5w-20 engine oil.