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In the rear differential of your 2010 Ford F-150, it's recommended to use SAE 75W-140 gear oil for better gear protection because of the small housing and rotating gears that can generate heat. Thicker oil like this provides better safeguarding compared to thinner oil that may not hold up under high temperatures. If you observe fluid leaking from the rear differential, it's advisable to replace the main gasket that seals it. It's also a good idea to inspect the differential fluid annually to ensure it's clean and free from debris or damage that could potentially damage the gears.
In a rear-wheel-drive vehicle, the differential is contained within its own casing and requires a specific type of thick, dark oil typically thicker than 80 weight for lubrication.