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The 2006 Ford F-250 uses Mercon LV Transmission Fluid and has a capacity of around 5.8 quarts. Transmission fluid is a type of lubricant, similar to oil, that helps protect the transmission's components from heat damage. The cost for a transmission fluid change on your F-250 typically ranges from $130 to $160 for labor and $400 for parts. It is recommended to have the transmission fluid replaced every 30,000 to 60,000 miles or every two to four years. Signs that your vehicle may need a transmission fluid change include a grinding noise from the transmission, difficulty shifting gears, slipping during gear changes, sudden surges, and a delay in movement after shifting into gear.
Ford suggests using Mercon V fluid for the transmission of the 2006 Ford F250.