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The 2000 Mercedes Benz E320 is well-known for its smooth and luxurious ride, and it's also considered to be a fairly dependable vehicle. While the E320 doesn't have many unique transmission problems, it's still essential to keep up with routine maintenance to avoid ending up in a tough spot like the rest of us. One frequently reported issue by drivers is transmission damage due to overheating. Overheating can occur for various reasons, with the primary one being carrying excessive weight or driving with low or degraded transmission fluid. It's recommended to change your fluid every 30,000 miles and check fluid levels every 5,000 miles or thereabouts. Following these guidelines can help prevent transmission problems by ensuring that the moving components are adequately lubricated.
One issue that has been reported with the 2000 Mercedes E320 is trouble shifting gears up, which is believed to be caused by a malfunctioning transmission control module.