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For your 2006 Chevrolet Silverado, it is recommended to use Dex-Cool that meets the Organic Acid Technology (OAT) requirements and the performance standards of ASTM D3306 and D4985. To simplify, opt for a 50/50 mix of orange coolant. An excellent option is AutoZone's NAOB53, priced around $20 per gallon, which complies with all GM vehicle specifications. It is advisable to replace this coolant every 50,000 miles, although it can last up to 100,000 miles. Over time, the organic acids and silicates may separate and settle out of the solution, causing potential damage to the engine metal. Given the affordability and ease of changing coolant, it is best not to delay flushing and refilling with fresh coolant to avoid this risk.
The 2006 Chevrolet Silverado is equipped with factory engine coolant.