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The 2005 Mercedes S500 takes synthetic motor oil 5w-40. It's a good idea to change your oil either every 7,500 miles or once a year, whichever comes first. Over time, oil can get thinner and more abrasive, causing wear on important engine parts. Synthetic oil is better for performance because it reduces friction and protects the engine. You can switch between synthetic and conventional oils without harming the engine. Synthetic blends are a mix of synthetic and conventional oils. Synthetic oil keeps engines cleaner by picking up debris and deposits that can damage them as it moves through the engine.
The recommended oil for a 2005 Mercedes S500 is Valvoline SynPower Synthetic Motor Oil 5W-40 in a one-quart size.