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First, ensure that the 2016 Ford F-250 is parked on even ground. Verify the tire pressure in each tire and ensure it matches the correct psi specified. The psi amount is usually imprinted on the side of the tire. Next, enter the vehicle and switch on the power without starting the engine. Locate the button labeled tpms or a similar name to the right of the steering wheel. Press and hold this button until it starts flashing. Allow the car to sit for approximately 20 minutes for recalibration. Once the flashing stops, turn off the car and restart it to confirm the reset.
The TPMS module for the 2016 Ford F250 is situated in the roof header, beneath the headliner on the left side of the rearview mirror assembly.