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If your Lexus IS250's paddle shifters are not functioning, the issue may be due to a blown fuse, which can also affect the cruise control. The fuse for the shifters is typically located inside the panel box. If you are not receiving any sensory feedback while using the shifters, check the fuse first. If only one shifter is working, it is probable that the paddle itself has malfunctioned. A replacement kit is available for around $240 on eBay, but replacing the paddle can be challenging. Before purchasing a replacement, inspect the steering wheel for loose wires as they may have become disconnected during a sudden turn or bump in the road.
If the paddle shifters on a Lexus IS 250 are not functioning, it may indicate a blown fuse or a problem with the linkage mechanism.