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One of the most common transmission issues you may come across with a 2008 Lexus LS460 is experiencing gear slipping when accelerating or difficulty in shifting gears. Fortunately, you can usually resolve both problems by either filling up low transmission fluid or replacing it if it's dirty or contaminated. If you drive without enough fluid, or if there are leaks causing fluid loss, you are likely to encounter these issues. More severe problems, such as gear wear, typically occur after driving your Lexus for a long time and will require professional attention, not something you can fix at home. However, in most cases, transmission problems are linked to fluid issues that can be resolved by using the correct ATF lubricant available from local suppliers.
In 2008, the Lexus LS 460 had issues with its transmission, such as slipping during shifts and experiencing difficulty when shifting.