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In the 2008 Lexus IS250 owner's manual, it is advised to typically use SAE 5W-30 engine oil. This choice is ideal for fuel efficiency and effective engine startup in cold temperatures. If SAE 5W-30 is unavailable, you can opt for 10W-30 as an alternative, but it's recommended for only one oil change; afterward, switch back to 5W-30. The amount of oil needed varies depending on whether your car is a 2WD or AWD model: 6.6 quarts for 2WD and 6.8 quarts for AWD, including the oil filter.
The recommended oil for a 2008 Lexus IS250 is Valvoline 5W-30 synthetic motor oil in a 5-quart container.