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There are a few potential issues that may arise with the transmission of a 2009 Mercedes E350. Most of the problems will result in difficulties with gear shifting. When experiencing transmission problems, the first step is to listen for increased noise while driving, which could indicate debris in the transmission or low fluid levels. These issues can lead to gear damage, causing excessive noise and improper shifting. Another common problem is poor shifting between gears, giving the sensation that the vehicle is struggling to find the right gear. This is often attributed to malfunctioning of the transmission control module, which may require replacement.
A few issues that may arise with the transmission of a 2009 Mercedes E350 include grinding gears, unresponsiveness, and contamination resulting from inadequate maintenance.