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The 2010 Mercedes GLK350 doesn't have any unique transmission problems, so the issues you may face are common ones like a sticky transmission or rough shifting. The good news is that these problems can often be resolved by simply checking your fluid level. If the transmission fluid is low or dirty from contaminants over time, it won't perform well and could eventually fail. Keeping it topped off or replacing it according to the manufacturer's recommended schedule can help prevent these transmission issues. You can use any synthetic ATF fluid for your GLK350; O'Reilly's offers a generic option for about $7, or for a little more, you can go with Valvoline's version.
Issues with changing gears in a 2010 Mercedes GLK350 may arise from insufficient transmission fluid or contamination resulting from neglecting maintenance.